Try this homemade Grandma Smith'S Tuna Casserole recipe the whole family will love. Made with tuna, cream of mushroom soup, sour cream and mayonnaise. E…
This Grandma Smith'S Tuna Casserole relies on simple, everyday ingredients such as sour cream, mayonnaise, cheddar cheese, grated and macaroni, cooked and hot. It comes together quickly and makes 4 servings, at about 844 kcal each. The step-by-step instructions below are written to be easy to follow, even on a busy day.
It's versatile enough for an easy weeknight dinner yet satisfying enough for guests at the weekend. Serve it with your favorite sides, and keep any leftovers for a quick meal the next day.
Updated Jun 30, 2026