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1
Cook bacon in 12-inch skillet over med-high heat until crisp, about 5 minutes.
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2
Stir in onions, chili powder, and paprika and cook until onions are softened and lightly browned, 8-10 minutes.
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3
Stir in ketchup, coffee, sugar, and 1 tablespoon mustard and simmer, until mixture is thickened and measures 4 cups, about 10 minutes.
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4
Transfer 2 cups of mixture to slow cooker; reserve remaining mixture separately.
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5
Season beef with salt and pepper and nestle into slow cooker.
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6
Cover and cook until beef is tender, 9-11 hours on LOW or 5-7 hours on HIGH.
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7
Transfer beef to large bowl, let cool slightly, then shred into bite-size pieces discarding excess fat; cover to keep warm.
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8
Let braising liquid settle for 5 minutes, then remove fat from surface using large spoon.
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9
Strain liquid into medium saucepan and simmer until thickened and measures 1 cup, 20-30 minutes.
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10
Whisk in reserved ketchup mixture, hot sauce, vinegar, remaining tablespoon mustard, and liquid smoke and bring to a simmer.
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11
Season with salt and pepper to taste.
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12
Toss shredded beef with 1 1/2 cups sauce; add more sauce as needed to keep meat moist.
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13
Serve with remaining sauce.