How many servings does this recipe make?

This recipe makes 4 servings. You can adjust the portion size directly on this page.

What ingredients do I need for Mexican Biscuit Casserole?

You need 16 ingredients. The key ingredients include: 2 (7 oz.) pkg. biscuits, 1 (1 lb.) pkg. hamburger, 1/2 c. chopped onions, 1 can Cheddar nacho cheese soup, and more.

Is Mexican Biscuit Casserole suitable as baking & desserts?

Yes, Mexican Biscuit Casserole falls under the Baking & Desserts category and is a great choice for this type of meal.

How do I store leftover Mexican Biscuit Casserole?

Store in an airtight container at room temperature for up to 3–5 days. For longer storage, freeze for up to 3 months — no need to refrigerate or reheat.

Mexican Biscuit Casserole Recipe

Name: Mexican Biscuit Casserole
Prep time: 15 min
Cook time: 30 min
Total time: 45 min
Yield: 4 servings
Ingredients: 2 (7 oz.) pkg. biscuits; 1 (1 lb.) pkg. hamburger; 1/2 c. chopped onions; 1 can Cheddar nacho cheese soup; 1 (8 oz.) can tomatoes; 2 tsp. mustard; 1/2 c. salsa; 1 c. shredded Mozzarella cheese; 2 lb. hamburger, browned and drained; 1 c. each: rotini, rigatoni and mostaccioli; 4 oz. pepperoni, sliced; 12 oz. Monterey Jack cheese, shredded; 1/2 c. onions, chopped; 1/2 c. green pepper, chopped; 1/2 c. ripe olives, chopped; 1 large jar spaghetti sauce (meat)

Bake this irresistible Mexican Biscuit Casserole at home. Made with biscuits, hamburger, onions and tomatoes. Easy step-by-step instructions included.

This Mexican Biscuit Casserole relies on simple, everyday ingredients such as (7 oz.) pkg. biscuits, (1 lb.) pkg. hamburger, chopped onions and cheddar nacho cheese soup. It comes together quickly and makes 4 servings, at about 1371 kcal each. The step-by-step instructions below are written to be easy to follow, even on a busy day.

Whether you're rounding off a family dinner, bringing a treat to a gathering, or simply satisfying a sweet craving, this Mexican Biscuit Casserole delivers. Serve it warm or at room temperature, and add a scoop of ice cream or a spoonful of whipped cream for an extra-special finish.

Updated Jun 30, 2026

Serves 4 Baking & Desserts

1371

kcal

Calories

Tips for the best results

Read through all the steps once before you start and measure out your ingredients first — it makes everything go more smoothly.
Preheat the oven fully and bake on the middle rack for the most even results.
Check for doneness a few minutes early — a toothpick in the center should come out with just a few moist crumbs.
Let it cool before slicing so it sets properly and holds its shape.
Store leftovers in an airtight container in the fridge and enjoy within a few days.

Variations & substitutions

Feel free to swap in similar ingredients you already have on hand and adjust seasoning to taste.

No specific allergen information. Please check the ingredient list for possible allergens.

My Personal Notes

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Mexican Biscuit Casserole

Tips for the best results

Variations & substitutions

My Personal Notes

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