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This Southwest Tuna Macaroni And Cheese Casserole relies on simple, everyday ingredients such as macaroni, milk (1 soup can full), margarine, cut into slivers and shredded cheddar cheese. It comes together quickly and makes 4 servings, at about 486 kcal each. The step-by-step instructions below are written to be easy to follow, even on a busy day.
It's versatile enough for an easy weeknight dinner yet satisfying enough for guests at the weekend. Serve it with your favorite sides, and keep any leftovers for a quick meal the next day.
Updated Jun 30, 2026