How many servings does this recipe make?

This recipe makes 4 servings. You can adjust the portion size directly on this page.

What ingredients do I need for Grandma'S Pepperoni Spaghetti Sauce?

You need 14 ingredients. The key ingredients include: 1 pound ground beef, 1 pound bulk Italian sausage (sweet or hot), 6 ounces sliced pepperoni, 1 large white onion, chopped medium, and more.

Is Grandma'S Pepperoni Spaghetti Sauce suitable as pasta & noodles?

Yes, Grandma'S Pepperoni Spaghetti Sauce falls under the Pasta & Noodles category and is a great choice for this type of meal.

How do I store leftover Grandma'S Pepperoni Spaghetti Sauce?

Store leftovers in an airtight container in the refrigerator for up to 3–4 days. Reheat gently before serving.

Grandma'S Pepperoni Spaghetti Sauce Recipe

Name: Grandma'S Pepperoni Spaghetti Sauce
Prep time: 15 min
Cook time: 30 min
Total time: 45 min
Yield: 4 servings
Ingredients: 1 pound ground beef; 1 pound bulk Italian sausage (sweet or hot); 6 ounces sliced pepperoni; 1 large white onion, chopped medium; 4-5 cloves garlic, minced; 46 ounces can tomato juice; 2 cans tomato sauce (30 oz. total); 2 cans tomato paste (12 oz. total); 2 teaspoons dried basil; 2 teaspoons dried oregano; 1/2 teaspoon cumin; 1 1/2 teaspoons salt; 1 1/2 teaspoons pepper; 1/2 teaspoon sugar

Try this homemade Grandma'S Pepperoni Spaghetti Sauce recipe the whole family will love. Made with ground beef, Italian sausage, pepperoni and white oni…

This Grandma'S Pepperoni Spaghetti Sauce relies on simple, everyday ingredients such as ground beef, sliced pepperoni, garlic, minced and can tomato juice. It comes together quickly and makes 4 servings, at about 603 kcal each. The step-by-step instructions below are written to be easy to follow, even on a busy day.

It's versatile enough for an easy weeknight dinner yet satisfying enough for guests at the weekend. Serve it with your favorite sides, and keep any leftovers for a quick meal the next day.

Updated Jun 30, 2026

Serves 4 Pasta & Noodles

Tips for the best results

Read through all the steps once before you start and measure out your ingredients first — it makes everything go more smoothly.
Taste as you go and adjust the seasoning before serving.
Avoid overcrowding the pan — cook in batches if needed for the best texture.
Let the dish rest for a few minutes before serving so the flavors settle.
Store leftovers in an airtight container in the fridge and enjoy within a few days.

Variations & substitutions

Brown sugar instead of white sugar adds a deeper, more caramel-like flavor.

No specific allergen information. Please check the ingredient list for possible allergens.

My Personal Notes

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Grandma'S Pepperoni Spaghetti Sauce

Tips for the best results

Variations & substitutions

My Personal Notes

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Frequently Asked Questions